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10.1186/s40634-016-0060-6 http://scihub22266oqcxt.onion/10.1186/s40634-016-0060-6 C5021646!5021646 !27624438     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27624438 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Orthop 2016 ; 3 (1 ): 22 Nephropedia Template TP {{tp|p=27624438 |t=2016. Basic science of osteoarthritis |pdf=|usr=}}{{27624438 }} gab.com Text Basic science of osteoarthritis JO: J Exp Orthop http://www.kidney.de/pget.php?&tw=1&pmid=27624438 #FOAvip Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option for the treatment of OA and may be used concomitantly with functional substitutes integrating scaffolds and drugs/growth factors in tissue engineering setups. Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA. Twit Text FOAVip Basic science of osteoarthritis ????J Exp Orthop http://www.kidney.de/pget.php?&tw=1&pmid=27624438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27624438 #FOAvip English Wikipedia <ref>{{Cite pmid|27624438 }}</ref> Basic science of osteoarthritis #MMPMID27624438 Cucchiarini M ; de Girolamo L ; Filardo G ; Oliveira JM ; Orth P ; Pape D ; Reboul P J Exp Orthop 2016[Dec]; 3 (1 ): 22 PMID27624438 show ga Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects a large population worldwide and for which there is no definitive cure. This review provides critical insights into the basic knowledge on OA that may lead to innovative end efficient new therapeutic regimens. While degradation of the articular cartilage is the hallmark of OA, with altered interactions between chondrocytes and compounds of the extracellular matrix, the subchondral bone has been also described as a key component of the disease, involving specific pathomechanisms controlling its initiation and progression. The identification of such events (and thus of possible targets for therapy) has been made possible by the availability of a number of animal models that aim at reproducing the human pathology, in particular large models of high tibial osteotomy (HTO). From a therapeutic point of view, mesenchymal stem cells (MSCs) represent a promising option for the treatment of OA and may be used concomitantly with functional substitutes integrating scaffolds and drugs/growth factors in tissue engineering setups. Altogether, these advances in the fundamental and experimental knowledge on OA may allow for the generation of improved, adapted therapeutic regimens to treat human OA. äBasic science of osteoarthritis (epmc).pdf DeepDyve Pubget Overpricing