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2015 ; 87
(ä): 15-24
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Basic biology and therapeutic implications of lncRNA
#MMPMID26024979
Khorkova O
; Hsiao J
; Wahlestedt C
Adv Drug Deliv Rev
2015[Jun]; 87
(ä): 15-24
PMID26024979
show ga
Long non-coding RNAs (lncRNA), a class of non-coding RNA molecules recently
identified largely due to the efforts of FANTOM, and later GENCODE and ENCODE
consortia, have been a subject of intense investigation in the past decade.
Extensive efforts to get deeper understanding of lncRNA biology have yielded
evidence of their diverse structural and regulatory roles in protecting
chromosome integrity, maintaining genomic architecture, X chromosome
inactivation, imprinting, transcription, translation and epigenetic regulation.
Here we will briefly review the recent studies in the field of lncRNA biology
focusing mostly on mammalian species and discuss their therapeutic implications.