Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26937279
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Cilia
2016 ; 5
(ä): 9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Basal body structure in Trichonympha
#MMPMID26937279
Guichard P
; Gönczy P
Cilia
2016[]; 5
(ä): 9
PMID26937279
show ga
Trichonympha is a symbiotic flagellate of many species of termites and of the
wood-feeding cockroach. Remarkably, this unicellular organism harbors up to over
ten thousand flagella on its surface, which serve to propel it through the
viscous environment of the host hindgut. In the 1960s, analysis of resin-embedded
Trichonympha samples by electron microscopy revealed that the basal bodies that
give rise to these flagella are exceptionally long, with a proximal,
cartwheel-bearing, region some 50 times longer than that of regular centrioles.
In recent years, this salient feature has prompted the analysis of the 3D
architecture of Trichonympha basal bodies in the native state using cryo-electron
tomography. The resulting ~40 Å resolution map of the basal body proximal region
revealed a number of novel features that may be conserved in centrioles of other
systems. These include proximal-distal polarity of the pinhead structure that
links the cartwheel to centriolar microtubules, as well as of the linker between
the A and the C microtubules. Moreover, this work demonstrated that the cartwheel
is made of stacked ring-like structures that likely each comprise 18 molecules of
SAS-6 proteins.