Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26311664
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Proc+Biol+Sci
2015 ; 282
(1814
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Bacteriocin-mediated competition in cystic fibrosis lung infections
#MMPMID26311664
Ghoul M
; West SA
; Johansen HK
; Molin S
; Harrison OB
; Maiden MC
; Jelsbak L
; Bruce JB
; Griffin AS
Proc Biol Sci
2015[Sep]; 282
(1814
): ä PMID26311664
show ga
Bacteriocins are toxins produced by bacteria to kill competitors of the same
species. Theory and laboratory experiments suggest that bacteriocin production
and immunity play a key role in the competitive dynamics of bacterial strains.
The extent to which this is the case in natural populations,especially human
pathogens, remains to be tested. We examined the role of bacteriocins in
competition using Pseudomonas aeruginosa strains infecting lungs of humans with
cystic fibrosis (CF). We assessed the ability of different strains to kill each
other using phenotypic assays, and sequenced their genomes to determine what
bacteriocins (pyocins) they carry. We found that(i) isolates from later infection
stages inhibited earlier infecting strains less,but were more inhibited by
pyocins produced by earlier infecting strains and carried fewer pyocin types;
(ii) this difference between early and late infections appears to be caused by a
difference in pyocin diversity between competing genotypes and not by loss of
pyocin genes within a lineage overtime; (iii) pyocin inhibition does not explain
why certain strains outcompete others within lung infections; (iv) strains
frequently carry the pyocin-killing gene, but not the immunity gene, suggesting
resistance occurs via other unknown mechanisms. Our results show that, in
contrast to patterns observed in experimental studies, pyocin production does not
appear to have a major influence on strain competition during CF lung infections.
free
free
free
