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2016 ; 371
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): ä Nephropedia Template TP
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Bacterial strategies of resistance to antimicrobial peptides
#MMPMID27160595
Joo HS
; Fu CI
; Otto M
Philos Trans R Soc Lond B Biol Sci
2016[May]; 371
(1695
): ä PMID27160595
show ga
Antimicrobial peptides (AMPs) are a key component of the host's innate immune
system, targeting invasive and colonizing bacteria. For successful survival and
colonization of the host, bacteria have a series of mechanisms to interfere with
AMP activity, and AMP resistance is intimately connected with the virulence
potential of bacterial pathogens. In particular, because AMPs are considered as
potential novel antimicrobial drugs, it is vital to understand bacterial AMP
resistance mechanisms. This review gives a comparative overview of Gram-positive
and Gram-negative bacterial strategies of resistance to various AMPs, such as
repulsion or sequestration by bacterial surface structures, alteration of
membrane charge or fluidity, degradation and removal by efflux pumps.This article
is part of the themed issue 'Evolutionary ecology of arthropod antimicrobial
peptides'.