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10.1007/s12223-025-01392-z http://scihub22266oqcxt.onion/10.1007/s12223-025-01392-z 41369836!?!41369836 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=41369836&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Folia+Microbiol+(Praha) 2025 ; ? (?): ? Nephropedia Template TP {{tp|p=41369836|t=2025. Bacterial pathogens in ventilator-associated pneumonia; molecular assessment of resistance profiles |pdf=|usr=}}{{41369836}} gab.com Text Bacterial pathogens in ventilator-associated pneumonia; molecular assessment of resistance profiles JO: Folia Microbiol (Praha) http://www.kidney.de/pget.php?&tw=1&pmid=41369836 #FOAvip Ventilator-associated pneumonia (VAP) is the most common infection encountered in intensive care units and is closely linked with elevated mortality, morbidity, and healthcare expenditure. The predominant pathogens responsible for VAP are multidrug-resistant (MDR) Gram-negative bacteria, including Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. This study aimed to investigate the molecular antibiotic resistance profiles of bacterial isolates from hospital-acquired VAP cases. Conducted between 30 November 2022 and 30 November 2023 at Kirsehir Training and Research Hospital, resistance genes were identified using Polymerase Chain Reaction (PCR), while clonal relatedness and genotyping were assessed through Repetitive Extragenic Palindromic-PCR (rep-PCR) and Multi-Locus Sequence Typing (MLST). The most frequently isolated organisms were A. baumannii (46.2%), K. pneumoniae (42.3%), and P. aeruginosa (7.7%). A. baumannii strains exhibited 100% resistance to ciprofloxacin and carbapenems, and 70.83% to colistin. K. pneumoniae strains demonstrated 94.73% resistance to carbapenems and 100% to piperacillin-tazobactam and colistin. Molecular analyses identified bla(TEM), bla(OXA-1), bla(CTX-M1), bla(OXA-51), bla(OXA-23), and bla(OXA-40) in A. baumannii, and bla(TEM), bla(SHV), bla(CTX-M1), bla(OXA-1), bla(OXA-48), and bla(NDM-1) in K. pneumoniae. Nine isolates (17%) were identified as transconjugants. MLST analysis revealed K. pneumoniae ST2096 and A. baumannii ST2 as predominant. Clones not previously reported in Turkiye A. baumannii ST78 and K. pneumoniae ST45, ST437, and ST1128 were also detected. This study provides a comprehensive molecular characterisation of VAP pathogens based on an extensive dataset. The results underscore the need for stricter infection control, restrained use of broad-spectrum antibiotics, and ongoing surveillance of resistance mechanisms. Twit Text FOAVip Bacterial pathogens in ventilator-associated pneumonia; molecular assessment of resistance profiles ????Folia Microbiol (Praha) http://www.kidney.de/pget.php?&tw=1&pmid=41369836 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=41369836 #FOAvip English Wikipedia <ref>{{Cite pmid|41369836}}</ref> Bacterial pathogens in ventilator-associated pneumonia; molecular assessment of resistance profiles #MMPMID41369836 Cam B; Hi?zmali? L; Sevi?m E; Akyol R Folia Microbiol (Praha) 2025[Dec]; ? (?): ? PMID41369836show ga Ventilator-associated pneumonia (VAP) is the most common infection encountered in intensive care units and is closely linked with elevated mortality, morbidity, and healthcare expenditure. The predominant pathogens responsible for VAP are multidrug-resistant (MDR) Gram-negative bacteria, including Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli. This study aimed to investigate the molecular antibiotic resistance profiles of bacterial isolates from hospital-acquired VAP cases. Conducted between 30 November 2022 and 30 November 2023 at Kirsehir Training and Research Hospital, resistance genes were identified using Polymerase Chain Reaction (PCR), while clonal relatedness and genotyping were assessed through Repetitive Extragenic Palindromic-PCR (rep-PCR) and Multi-Locus Sequence Typing (MLST). The most frequently isolated organisms were A. baumannii (46.2%), K. pneumoniae (42.3%), and P. aeruginosa (7.7%). A. baumannii strains exhibited 100% resistance to ciprofloxacin and carbapenems, and 70.83% to colistin. K. pneumoniae strains demonstrated 94.73% resistance to carbapenems and 100% to piperacillin-tazobactam and colistin. Molecular analyses identified bla(TEM), bla(OXA-1), bla(CTX-M1), bla(OXA-51), bla(OXA-23), and bla(OXA-40) in A. baumannii, and bla(TEM), bla(SHV), bla(CTX-M1), bla(OXA-1), bla(OXA-48), and bla(NDM-1) in K. pneumoniae. Nine isolates (17%) were identified as transconjugants. MLST analysis revealed K. pneumoniae ST2096 and A. baumannii ST2 as predominant. Clones not previously reported in Turkiye A. baumannii ST78 and K. pneumoniae ST45, ST437, and ST1128 were also detected. This study provides a comprehensive molecular characterisation of VAP pathogens based on an extensive dataset. The results underscore the need for stricter infection control, restrained use of broad-spectrum antibiotics, and ongoing surveillance of resistance mechanisms. ?Bacterial pathogens in ventilator-associated pneumonia; molecular asse(epmc).pdf DeepDyve Pubget Overpricing