Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25677995
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Clin Perinatol
2015[Mar]; 42
(1
): 29-45, vii-viii
PMID25677995
show ga
Neonatal bacterial meningitis is uncommon but devastating. Morbidity among
survivors remains high. The types and distribution of pathogens are related to
gestational age, postnatal age, and geographic region. Confirming the diagnosis
is difficult. Clinical signs are often subtle, lumbar punctures are frequently
deferred, and cerebrospinal fluid (CSF) cultures can be compromised by prior
antibiotic exposure. Infants with bacterial meningitis can have negative blood
cultures and normal CSF parameters. Promising tests such as the polymerase chain
reaction require further study. Prompt treatment with antibiotics is essential.
Clinical trials investigating a vaccine for preventing neonatal Group B
Streptococcus infections are ongoing.