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10.1016/j.sjbs.2014.10.002

http://scihub22266oqcxt.onion/10.1016/j.sjbs.2014.10.002
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C4486731!4486731 !26150740
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suck abstract from ncbi

pmid26150740
      Saudi+J+Biol+Sci 2015 ; 22 (4 ): 359-73
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  • BRAF gene: From human cancers to developmental syndromes #MMPMID26150740
  • Hussain MR ; Baig M ; Mohamoud HS ; Ulhaq Z ; Hoessli DC ; Khogeer GS ; Al-Sayed RR ; Al-Aama JY
  • Saudi J Biol Sci 2015[Jul]; 22 (4 ): 359-73 PMID26150740 show ga
  • The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes-Noonan syndrome, cardio-facio-cutaneous syndrome and LEOPARD syndrome.
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