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2015 ; 349
(6251
): 936
Nephropedia Template TP
gab.com Text
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English Wikipedia
BIOPHYSICS Comment on "Extreme electric fields power catalysis in the active
site of ketosteroid isomerase"
#MMPMID26315427
Chen D
; Savidge T
Science
2015[Aug]; 349
(6251
): 936
PMID26315427
show ga
Fried et al. (Reports, 19 December 2014, p. 1510) demonstrate electric
field-dependent acceleration of biological catalysis using ketosteroid isomerase
as a prototypic example. These findings were not extended to aqueous solution
because water by itself has field fluctuations that are too large and fast to
provide a catalytic effect. Given physiological context, when water electrostatic
interactions are considered, electric fields play a less important role in the
catalysis.