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2017 ; 11
(3
): 213-218
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B lymphocytes in renal interstitial fibrosis
#MMPMID28210941
Zhu F
; Bai X
; Chen X
J Cell Commun Signal
2017[Sep]; 11
(3
): 213-218
PMID28210941
show ga
Fibrosis is defined as an excessive deposition of extracellular matrix (ECM),
which leads to the destruction of organ structure and impairment of organ
function. Fibrosis occurs not only in kidney but also in lung, liver, heart, and
skin. Common pathways of fibrosis are thought to exist. Renal interstitial
fibrosis is a complex process that involves multiple molecular signaling and
multiple cellular components, in which B cells appear to be one of the emerging
important players. B cells may affect fibrosis through cytokine production and
through interaction with other cells including fibroblasts, macrophages and T
cells. This review summarizes recent research findings of B cells in fibrosis and
provides an insight of how the future therapeutics of fibrosis could be developed
from a B-cell point of view.
free
free
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