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2017 ; 7
(ä): 65
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Autophagy-Regulating microRNAs and Cancer
#MMPMID28459042
Gozuacik D
; Akkoc Y
; Ozturk DG
; Kocak M
Front Oncol
2017[]; 7
(ä): 65
PMID28459042
show ga
Macroautophagy (autophagy herein) is a cellular stress response and a survival
pathway that is responsible for the degradation of long-lived proteins, protein
aggregates, as well as damaged organelles in order to maintain cellular
homeostasis. Consequently, abnormalities of autophagy are associated with a
number of diseases, including Alzheimers's disease, Parkinson's disease, and
cancer. According to the current view, autophagy seems to serve as a tumor
suppressor in the early phases of cancer formation, yet in later phases,
autophagy may support and/or facilitate tumor growth, spread, and contribute to
treatment resistance. Therefore, autophagy is considered as a stage-dependent
dual player in cancer. microRNAs (miRNAs) are endogenous non-coding small RNAs
that negatively regulate gene expression at a post-transcriptional level. miRNAs
control several fundamental biological processes, and autophagy is no exception.
Furthermore, accumulating data in the literature indicate that dysregulation of
miRNA expression contribute to the mechanisms of cancer formation, invasion,
metastasis, and affect responses to chemotherapy or radiotherapy. Therefore,
considering the importance of autophagy for cancer biology, study of
autophagy-regulating miRNA in cancer will allow a better understanding of
malignancies and lead to the development of novel disease markers and therapeutic
strategies. The potential to provide study of some of these cancer-related miRNAs
were also implicated in autophagy regulation. In this review, we will focus on
autophagy, miRNA, and cancer connection, and discuss its implications for cancer
biology and cancer treatment.