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Autophagy: machinery and regulation
#MMPMID28357331
Yin Z
; Pascual C
; Klionsky DJ
Microb Cell
2016[Dec]; 3
(12
): 588-596
PMID28357331
show ga
Macroautophagy/autophagy is an evolutionarily conserved cellular degradation
process that targets cytoplasmic materials including cytosol, macromolecules and
unwanted organelles. The discovery and analysis of autophagy-related (Atg)
proteins have unveiled much of the machinery of autophagosome formation. Although
initially autophagy was regarded as a survival response to stress, recent studies
have revealed its significance in cellular and organismal homeostasis,
development and immunity. Autophagic dysfunction and dysregulation are implicated
in various diseases. In this review, we briefly summarize the physiological
roles, molecular mechanism, regulatory network, and pathophysiological roles of
autophagy.