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10.1038/cr.2014.105 http://scihub22266oqcxt.onion/10.1038/cr.2014.105 C4152733!4152733 !25104734     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25104734 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Res 2014 ; 24 (9 ): 1029-30 Nephropedia Template TP {{tp|p=25104734 |t=2014. Autophagy regulation: RNF2 targets AMBRA1 |pdf=|usr=}}{{25104734 }} gab.com Text Autophagy regulation: RNF2 targets AMBRA1 JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=25104734 #FOAvip The phosphatidylinositol 3-kinase complex I (PI3K complex I) is a crucial regulator of autophagy, which contains Beclin 1 (or ATG6), ATG14L, VPS34 (or the class III phosphatidylinositol 3-kinase and its adaptor VPS15) and AMBRA1, and controls autophagosome formation. In a paper recently published in Cell Research, Xia et al. report that during nutrient deprivation the ubiquitin E3 ligase RNF2 is recruited to the PI3K complex I, and ubiquitinates AMBRA1 to trigger its degradation and downregulate autophagy. Twit Text FOAVip Autophagy regulation: RNF2 targets AMBRA1 ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=25104734 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25104734 #FOAvip English Wikipedia <ref>{{Cite pmid|25104734 }}</ref> Autophagy regulation: RNF2 targets AMBRA1 #MMPMID25104734 Morel E ; Dupont N ; Codogno P Cell Res 2014[Sep]; 24 (9 ): 1029-30 PMID25104734 show ga The phosphatidylinositol 3-kinase complex I (PI3K complex I) is a crucial regulator of autophagy, which contains Beclin 1 (or ATG6), ATG14L, VPS34 (or the class III phosphatidylinositol 3-kinase and its adaptor VPS15) and AMBRA1, and controls autophagosome formation. In a paper recently published in Cell Research, Xia et al. report that during nutrient deprivation the ubiquitin E3 ligase RNF2 is recruited to the PI3K complex I, and ubiquitinates AMBRA1 to trigger its degradation and downregulate autophagy. |*Autophagy [MESH] |Adaptor Proteins, Signal Transducing/*metabolism [MESH] |Animals [MESH] |Microfilament Proteins/*metabolism [MESH] |Polycomb Repressive Complex 1/*metabolism [MESH] |Ubiquitin-Protein Ligases/*metabolism [MESH]Autophagy regulation: RNF2 targets AMBRA1 (epmc).pdf DeepDyve Pubget Overpricing