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10.1016/j.chom.2015.03.001 http://scihub22266oqcxt.onion/10.1016/j.chom.2015.03.001 C4392646!4392646 !25816775     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25816775 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25816775 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Host+Microbe 2015 ; 17 (4 ): 429-40 Nephropedia Template TP {{tp|p=25816775 |t=2015. Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin |pdf=|usr=}}{{25816775 }} gab.com Text Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=25816775 #FOAvip Resistance and tolerance are two defense strategies employed by the host against microbial threats. Autophagy-mediated degradation of bacteria has been extensively described as a major resistance mechanism. Here we find that the dominant function of autophagy proteins during infections with the epidemic community-associated methicillin-resistant Staphylococcus aureus USA300 is to mediate tolerance rather than resistance. Atg16L1 hypomorphic mice (Atg16L1(HM)), which have reduced autophagy, were highly susceptible to lethality in both sepsis and pneumonia models of USA300 infection. Autophagy confers protection by limiting the damage caused by ?-toxin, particularly to endothelial cells. Remarkably, Atg16L1(HM) mice display enhanced survival rather than susceptibility upon infection with ?-toxin-deficient S. aureus. These results identify an essential role for autophagy in tolerance to Staphylococcal disease and highlight how a single virulence factor encoded by a pathogen can determine whether a given host factor promotes tolerance or resistance. Twit Text FOAVip Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=25816775 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25816775 #FOAvip English Wikipedia <ref>{{Cite pmid|25816775 }}</ref> Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin #MMPMID25816775 Maurer K ; Reyes-Robles T ; Alonzo F 3rd ; Durbin J ; Torres VJ ; Cadwell K Cell Host Microbe 2015[Apr]; 17 (4 ): 429-40 PMID25816775 show ga Resistance and tolerance are two defense strategies employed by the host against microbial threats. Autophagy-mediated degradation of bacteria has been extensively described as a major resistance mechanism. Here we find that the dominant function of autophagy proteins during infections with the epidemic community-associated methicillin-resistant Staphylococcus aureus USA300 is to mediate tolerance rather than resistance. Atg16L1 hypomorphic mice (Atg16L1(HM)), which have reduced autophagy, were highly susceptible to lethality in both sepsis and pneumonia models of USA300 infection. Autophagy confers protection by limiting the damage caused by ?-toxin, particularly to endothelial cells. Remarkably, Atg16L1(HM) mice display enhanced survival rather than susceptibility upon infection with ?-toxin-deficient S. aureus. These results identify an essential role for autophagy in tolerance to Staphylococcal disease and highlight how a single virulence factor encoded by a pathogen can determine whether a given host factor promotes tolerance or resistance. |*Autophagy [MESH] |*Immune Tolerance [MESH] |Animals [MESH] |Autophagy-Related Proteins [MESH] |Bacterial Toxins/*immunology [MESH] |Carrier Proteins/genetics [MESH] |Hemolysin Proteins/*immunology [MESH] |Methicillin-Resistant Staphylococcus aureus/*immunology [MESH] |Mice, Knockout [MESH] |Pneumonia, Staphylococcal/immunology/microbiology [MESH] |Sepsis/immunology/microbiology [MESH]Autophagy mediates tolerance to Staphylococcus aureus alpha-toxin (epmc).pdf DeepDyve Pubget Overpricing