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10.3892/mmr.2016.5807 http://scihub22266oqcxt.onion/10.3892/mmr.2016.5807 C5102028!5102028 !27748808     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27748808 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2016 ; 14 (5 ): 4638-4642 Nephropedia Template TP {{tp|p=27748808 |t=2016. Autophagy is involved in aldosterone?induced mesangial cell proliferation |pdf=|usr=}}{{27748808 }} gab.com Text Autophagy is involved in aldosterone induced mesangial cell proliferation JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=27748808 #FOAvip The aim of the present study was to investigate whether autophagy is involved in aldosterone (Aldo)-induced mesangial cell (MC) proliferation. MCs were incubated with 10?7 M Aldo for 24 h. Proliferation of MCs, and the underlying mechanisms, were subsequently analyzed using [3H]thymidine assay, cell counting assay, western blotting and RNA interference (RNAi). Aldo was revealed to induce autophagy, as indicated by the increased conversion from microtubule?associated protein 1A/1B?light chain 3 (LC3)?I to LC3?II, the increased expression levels of autophagy?related gene 7 (Atg7) and the increased degradation of p62, which was accompanied by MC proliferation. Notably, pharmacological inhibition of autophagy or RNAi?mediated knockdown of Atg7 attenuated Aldo?induced MC proliferation, suggesting that autophagy was at least partially responsible for this effect. The results of the present study provided evidence that autophagy is critical for regulating Aldo?induced MC proliferation. Twit Text FOAVip Autophagy is involved in aldosterone induced mesangial cell proliferation ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=27748808 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27748808 #FOAvip English Wikipedia <ref>{{Cite pmid|27748808 }}</ref> Autophagy is involved in aldosterone?induced mesangial cell proliferation #MMPMID27748808 Yang M ; Wang B ; Miao L ; Xu X ; He X Mol Med Rep 2016[Nov]; 14 (5 ): 4638-4642 PMID27748808 show ga The aim of the present study was to investigate whether autophagy is involved in aldosterone (Aldo)-induced mesangial cell (MC) proliferation. MCs were incubated with 10?7 M Aldo for 24 h. Proliferation of MCs, and the underlying mechanisms, were subsequently analyzed using [3H]thymidine assay, cell counting assay, western blotting and RNA interference (RNAi). Aldo was revealed to induce autophagy, as indicated by the increased conversion from microtubule?associated protein 1A/1B?light chain 3 (LC3)?I to LC3?II, the increased expression levels of autophagy?related gene 7 (Atg7) and the increased degradation of p62, which was accompanied by MC proliferation. Notably, pharmacological inhibition of autophagy or RNAi?mediated knockdown of Atg7 attenuated Aldo?induced MC proliferation, suggesting that autophagy was at least partially responsible for this effect. The results of the present study provided evidence that autophagy is critical for regulating Aldo?induced MC proliferation. |Aldosterone/administration & dosage [MESH] |Apoptosis/genetics [MESH] |Autophagy-Related Protein 7/antagonists & inhibitors/biosynthesis/*genetics [MESH] |Autophagy/*genetics [MESH] |Cell Line [MESH] |Cell Proliferation/*genetics [MESH] |Gene Expression Regulation/drug effects [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Mesangial Cells/cytology/drug effects/metabolism [MESH] |Proteolysis/drug effects [MESH] |RNA Interference [MESH]Autophagy is involved in aldosterone?induced mesangial cell proliferat(epmc).pdf DeepDyve Pubget Overpricing