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2017 ; 60
(3
): 241-259
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Autophagy in the placenta
#MMPMID28534010
Oh SY
; Roh CR
Obstet Gynecol Sci
2017[May]; 60
(3
): 241-259
PMID28534010
show ga
Autophagy is an evolutionarily conserved catalytic process by which cytoplasmic
components including damaged macromolecules and organelles are degraded. The role
of autophagy includes adaptive responses to nutrition deprivation or
intracellular stimuli. Although autophagosomes were first observed in early
1960s, it was 1990s that autophagy-related genes in yeast were identified and
studied. Nowadays, the molecular machinery of autophagy and signaling pathway to
various stimuli are almost outlined. Dysregulation of autophagic activity has
been implicated in many human diseases including neurodegenerative diseases,
infection and inflammation, and malignancies. However, since current
understanding of autophagy in placenta is just at the beginning, this paper aims
to provide general information on autophagy (part I) and to summarize articles on
autophagy in human placenta (part II). This review article will serve as a basis
for further researches on autophagy in relation to human pregnancy and its
complications.
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