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10.15252/embj.201490784 http://scihub22266oqcxt.onion/10.15252/embj.201490784 C4388596!4388596!25712477     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25712477.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2015 ; 34 (7): 856-80 Nephropedia Template TP {{tp|p=25712477|t=2015. Autophagy in malignant transformation and cancer progression |pdf=|usr=}}{{25712477}} gab.com Text Autophagy in malignant transformation and cancer progression JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25712477 #FOAvip Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy. Twit Text FOAVip Autophagy in malignant transformation and cancer progression ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=25712477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25712477 #FOAvip English Wikipedia <ref>{{Cite pmid|25712477}}</ref> Autophagy in malignant transformation and cancer progression #MMPMID25712477 Galluzzi L; Pietrocola F; Bravo-San Pedro JM; Amaravadi RK; Baehrecke EH; Cecconi F; Codogno P; Debnath J; Gewirtz DA; Karantza V; Kimmelman A; Kumar S; Levine B; Maiuri MC; Martin SJ; Penninger J; Piacentini M; Rubinsztein DC; Simon HU; Simonsen A; Thorburn AM; Velasco G; Ryan KM; Kroemer G EMBO J 2015[Apr]; 34 (7): 856-80 PMID25712477show ga Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy. äAutophagy in malignant transformation and cancer progression (epmc).pdf DeepDyve Pubget Overpricing