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2015 ; 5
(ä): 49
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Autophagy in Mycobacterium tuberculosis and HIV infections
#MMPMID26082897
Espert L
; Beaumelle B
; Vergne I
Front Cell Infect Microbiol
2015[]; 5
(ä): 49
PMID26082897
show ga
Human Immunodeficiency Virus (HIV) and Mycobacterium tuberculosis (M.tb) are
among the most lethal human pathogens worldwide, each being responsible for
around 1.5 million deaths annually. Moreover, synergy between acquired immune
deficiency syndrome (AIDS) and tuberculosis (TB) has turned HIV/M.tb co-infection
into a major public health threat in developing countries. In the past decade,
autophagy, a lysosomal catabolic process, has emerged as a major host immune
defense mechanism against infectious agents like M.tb and HIV. Nevertheless, in
some instances, autophagy machinery appears to be instrumental for HIV infection.
Finally, there is mounting evidence that both pathogens deploy various
countermeasures to thwart autophagy. This mini-review proposes an overview of the
roles and regulations of autophagy in HIV and M.tb infections with an emphasis on
microbial factors. We also discuss the role of autophagy manipulation in the
context of HIV/M.tb co-infection. In future, a comprehensive understanding of
autophagy interaction with these pathogens will be critical for development of
autophagy-based prophylactic and therapeutic interventions for AIDS and TB.
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