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10.1038/ncomms13508 http://scihub22266oqcxt.onion/10.1038/ncomms13508 C5473638!5473638 !27869116     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27869116 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 13508 Nephropedia Template TP {{tp|p=27869116 |t=2016. Autophagy controls centrosome number by degrading Cep63 |pdf=|usr=}}{{27869116 }} gab.com Text Autophagy controls centrosome number by degrading Cep63 JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27869116 #FOAvip Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin-proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63 (Cep63) given that cells lacking autophagy contain multiple Cep63 dots that are engulfed and digested by autophagy in wild-type cells, and that the upregulation of Cep63 increases centrosome number. Cep63 is recruited to autophagosomes via interaction with p62, a molecule crucial for selective autophagy. In vivo, hematopoietic cells from autophagy-deficient and p62(-/-) mice also contained multiple centrosomes. These results indicate that autophagy controls centrosome number by degrading Cep63. Twit Text FOAVip Autophagy controls centrosome number by degrading Cep63 ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=27869116 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27869116 #FOAvip English Wikipedia <ref>{{Cite pmid|27869116 }}</ref> Autophagy controls centrosome number by degrading Cep63 #MMPMID27869116 Watanabe Y ; Honda S ; Konishi A ; Arakawa S ; Murohashi M ; Yamaguchi H ; Torii S ; Tanabe M ; Tanaka S ; Warabi E ; Shimizu S Nat Commun 2016[Nov]; 7 (ä): 13508 PMID27869116 show ga Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin-proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63 (Cep63) given that cells lacking autophagy contain multiple Cep63 dots that are engulfed and digested by autophagy in wild-type cells, and that the upregulation of Cep63 increases centrosome number. Cep63 is recruited to autophagosomes via interaction with p62, a molecule crucial for selective autophagy. In vivo, hematopoietic cells from autophagy-deficient and p62(-/-) mice also contained multiple centrosomes. These results indicate that autophagy controls centrosome number by degrading Cep63. |*Autophagy [MESH] |*Centrosome [MESH] |Animals [MESH] |Autophagy-Related Protein 5/metabolism [MESH] |Autophagy-Related Protein 7/genetics/metabolism [MESH] |Cell Cycle Proteins/genetics/*metabolism [MESH] |Cells, Cultured [MESH] |Humans [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Neoplasm Proteins/genetics/*metabolism [MESH]Autophagy controls centrosome number by degrading Cep63 (epmc).pdf DeepDyve Pubget Overpricing