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10.1016/j.gde.2014.04.003 http://scihub22266oqcxt.onion/10.1016/j.gde.2014.04.003 C4253630!4253630 !24907664     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24907664 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24907664 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Genet+Dev 2014 ; 26 (ä): 16-23 Nephropedia Template TP {{tp|p=24907664 |t=2014. Autophagy and human disease: emerging themes |pdf=|usr=}}{{24907664 }} gab.com Text Autophagy and human disease: emerging themes JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=24907664 #FOAvip Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the reasons behind the autophagic defect, the immediate consequences of the autophagic compromise and how autophagy changes with the evolution of the disease has become a 'must,' especially now that manipulation of autophagy is being considered as a therapeutic strategy. Here, we comment on some of the common themes that have emerged from such detailed analyses of the interplay between autophagy and disease conditions. Twit Text FOAVip Autophagy and human disease: emerging themes ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=24907664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24907664 #FOAvip English Wikipedia <ref>{{Cite pmid|24907664 }}</ref> Autophagy and human disease: emerging themes #MMPMID24907664 Schneider JL ; Cuervo AM Curr Opin Genet Dev 2014[Jun]; 26 (ä): 16-23 PMID24907664 show ga Malfunction of autophagy, the process that mediates breakdown and recycling of intracellular components in lysosomes, has been linked to a variety of human diseases. As the number of pathologies associated with defective autophagy increases, emphasis has switched from the mere description of the status of autophagy in these conditions to a more mechanistic dissection of the autophagic changes. Understanding the reasons behind the autophagic defect, the immediate consequences of the autophagic compromise and how autophagy changes with the evolution of the disease has become a 'must,' especially now that manipulation of autophagy is being considered as a therapeutic strategy. Here, we comment on some of the common themes that have emerged from such detailed analyses of the interplay between autophagy and disease conditions. |*Autophagy [MESH] |Humans [MESH] |Lysosomal Storage Diseases/genetics/*metabolism/pathology [MESH] |Lysosomes/*metabolism [MESH] |Models, Biological [MESH] |Mutant Proteins/genetics/metabolism [MESH] |Mutation [MESH] |Neurodegenerative Diseases/genetics/*metabolism/pathology [MESH] |Phagosomes/*metabolism [MESH]Autophagy and human disease: emerging themes (epmc).pdf DeepDyve Pubget Overpricing