Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28095319
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Clin Immunol
2017[Mar]; 176
(?): 55-62
PMID28095319
show ga
Autophagy is a highly conserved protein degradation pathway from yeasts to humans
that is essential for removing protein aggregates and misfolded proteins in
healthy cells. Recently, autophagy-related genes polymorphisms have been
implicated in several autoimmune diseases including systemic lupus erythematosus,
rheumatoid arthritis, psoriasis, and multiple sclerosis. Numerous studies reveal
autophagy and autophagy-related proteins also participate in immune regulation.
Conditional deletions of autophagy-related proteins in mice have rendered
protection from experimental autoimmune encephalomyelitis, and TNF-mediated joint
destruction in animal models of multiple sclerosis and experimental arthritis
respectively. As autophagy is strongly implicated in immune functions such as
removal of intracellular bacteria, inflammatory cytokine secretion, antigen
presentation, and lymphocyte development, in this review we summarized current
understanding of the roles of autophagy and autophagy proteins in autoimmune
diseases.