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2016 ; 35
(17
): 1845-7
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Autophagosome-lysosome fusion: PIs to the rescue
#MMPMID27440401
Li L
; Zhong Q
EMBO J
2016[Sep]; 35
(17
): 1845-7
PMID27440401
show ga
Phosphoinositides (PIs), a small fraction of the cellular lipids, function in
almost all cellular physiological processes and especially in intracellular
membrane trafficking events. PIs play a critical role in autophagy, but only
PI(3)P is well studied. In this issue of The EMBO Journal, Hasegawa et al (2016)
identified INPP5E, an inositol polyphosphate 5?phosphatase, as a novel regulator
of autophagy. INPP5E controls the level of PI(3,5)P(2) at the lysosome and
thereby locally regulates the actin cytoskeleton and autophagosome?lysosome
fusion.