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2015 ; 16
(8
): 16920-52
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Autonomic Dysregulation in Multiple Sclerosis
#MMPMID26213927
Pintér A
; Cseh D
; Sárközi A
; Illigens BM
; Siepmann T
Int J Mol Sci
2015[Jul]; 16
(8
): 16920-52
PMID26213927
show ga
Multiple sclerosis (MS) is a chronic, progressive central neurological disease
characterized by inflammation and demyelination. In patients with MS,
dysregulation of the autonomic nervous system may present with various clinical
symptoms including sweating abnormalities, urinary dysfunction, orthostatic
dysregulation, gastrointestinal symptoms, and sexual dysfunction. These autonomic
disturbances reduce the quality of life of affected patients and constitute a
clinical challenge to the physician due to variability of clinical presentation
and inconsistent data on diagnosis and treatment. Early diagnosis and initiation
of individualized interdisciplinary and multimodal strategies is beneficial in
the management of autonomic dysfunction in MS. This review summarizes the current
literature on the most prevalent aspects of autonomic dysfunction in MS and
provides reference to underlying pathophysiological mechanisms as well as means
of diagnosis and treatment.