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2014 ; 102 Pt 2
(0 2
): 596-607
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Automated tract extraction via atlas based Adaptive Clustering
#MMPMID25134977
Tunç B
; Parker WA
; Ingalhalikar M
; Verma R
Neuroimage
2014[Nov]; 102 Pt 2
(0 2
): 596-607
PMID25134977
show ga
Advancements in imaging protocols such as the high angular resolution
diffusion-weighted imaging (HARDI) and in tractography techniques are expected to
cause an increase in the tract-based analyses. Statistical analyses over white
matter tracts can contribute greatly towards understanding structural mechanisms
of the brain since tracts are representative of connectivity pathways. The main
challenge with tract-based studies is the extraction of the tracts of interest in
a consistent and comparable manner over a large group of individuals without
drawing the inclusion and exclusion regions of interest. In this work, we design
a framework for automated extraction of white matter tracts. The framework
introduces three main components, namely a connectivity based fiber
representation, a fiber bundle atlas, and a clustering approach called Adaptive
Clustering. The fiber representation relies on the connectivity signatures of
fibers to establish an easy correspondence between different subjects. A
group-wise clustering of these fibers that are represented by the connectivity
signatures is then used to generate a fiber bundle atlas. Finally, Adaptive
Clustering incorporates the previously generated clustering atlas as a prior, to
cluster the fibers of a new subject automatically. Experiments on the HARDI scans
of healthy individuals acquired repeatedly, demonstrate the applicability,
reliability and the repeatability of our approach in extracting white matter
tracts. By alleviating the seed region selection and the inclusion/exclusion ROI
drawing requirements that are usually handled by trained radiologists, the
proposed framework expands the range of possible clinical applications and
establishes the ability to perform tract-based analyses with large samples.
|Adult
[MESH]
|Algorithms
[MESH]
|Brain/*anatomy & histology
[MESH]
|Cluster Analysis
[MESH]
|Diffusion Magnetic Resonance Imaging/*methods
[MESH]