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10.1016/j.molmed.2016.05.003 http://scihub22266oqcxt.onion/10.1016/j.molmed.2016.05.003 C4925313!4925313 !27267764     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27267764 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Mol+Med 2016 ; 22 (7 ): 545-564 Nephropedia Template TP {{tp|p=27267764 |t=2016. Autoinflammatory Skin Disorders: The Inflammasomme in Focus |pdf=|usr=}}{{27267764 }} gab.com Text Autoinflammatory Skin Disorders: The Inflammasomme in Focus JO: Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27267764 #FOAvip Autoinflammatory skin disorders are a group of heterogeneous diseases that include diseases such as cryopyrin-associated periodic syndrome (CAPS) and familial Mediterranean fever (FMF). Therapeutic strategies targeting IL-1 cytokines have proved helpful in ameliorating some of these diseases. While inflammasomes are the major regulators of IL-1 cytokines, inflammasome-independent complexes can also process IL-1 cytokines. Herein, we focus on recent advances in our understanding of how IL-1 cytokines, stemming from inflammasome-dependent and -independent pathways are involved in the regulation of skin conditions. Importantly, we discuss several mouse models of skin inflammation generated to help elucidate the basic cellular and molecular effects and modulation of IL-1 in the skin. Such models offer perspectives on how these signaling pathways could be targeted to improve therapeutic approaches in the treatment of these rare and debilitating inflammatory skin disorders. Twit Text FOAVip Autoinflammatory Skin Disorders: The Inflammasomme in Focus ????Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=27267764 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27267764 #FOAvip English Wikipedia <ref>{{Cite pmid|27267764 }}</ref> Autoinflammatory Skin Disorders: The Inflammasomme in Focus #MMPMID27267764 Gurung P ; Kanneganti TD Trends Mol Med 2016[Jul]; 22 (7 ): 545-564 PMID27267764 show ga Autoinflammatory skin disorders are a group of heterogeneous diseases that include diseases such as cryopyrin-associated periodic syndrome (CAPS) and familial Mediterranean fever (FMF). Therapeutic strategies targeting IL-1 cytokines have proved helpful in ameliorating some of these diseases. While inflammasomes are the major regulators of IL-1 cytokines, inflammasome-independent complexes can also process IL-1 cytokines. Herein, we focus on recent advances in our understanding of how IL-1 cytokines, stemming from inflammasome-dependent and -independent pathways are involved in the regulation of skin conditions. Importantly, we discuss several mouse models of skin inflammation generated to help elucidate the basic cellular and molecular effects and modulation of IL-1 in the skin. Such models offer perspectives on how these signaling pathways could be targeted to improve therapeutic approaches in the treatment of these rare and debilitating inflammatory skin disorders. |Animals [MESH] |Cryopyrin-Associated Periodic Syndromes/*immunology/pathology [MESH] |Disease Models, Animal [MESH] |Familial Mediterranean Fever/*immunology/pathology [MESH] |Humans [MESH] |Inflammasomes/*immunology [MESH] |Interleukin-1/*immunology [MESH]Autoinflammatory Skin Disorders: The Inflammasomme in Focus (epmc).pdf DeepDyve Pubget Overpricing