Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28626447
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Front+Endocrinol+(Lausanne)
2017 ; 8
(ä): 119
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Autoimmune Thyroiditis and Glomerulopathies
#MMPMID28626447
Santoro D
; Vadalà C
; Siligato R
; Buemi M
; Benvenga S
Front Endocrinol (Lausanne)
2017[]; 8
(ä): 119
PMID28626447
show ga
Autoimmune thyroiditis (AIT) is generally associated with hypothyroidism. It
affects ~2% of the female population and 0.2% of the male population. The
evidence of thyroid function- and thyroid autoantibody-unrelated microproteinuria
in almost half of patients with AIT and sometimes heavy proteinuria as in the
nephrotic syndrome point to a link of AIT with renal disease. The most common
renal diseases observed in AIT are membranous nephropathy, membranoproliferative
glomerulonephritis, minimal change disease, IgA nephropathy, focal segmental
glomerulosclerosis, antineutrophil cytoplasmic autoantibody (ANCA) vasculitis,
and amyloidosis. Different hypotheses have been put forward regarding the
relationship between AIT and glomerulopathies, and several potential mechanisms
for this association have been considered. Glomerular deposition of
immunocomplexes of thyroglobulin and autoantibodies as well as the impaired
immune tolerance for megalin (a thyrotropin-regulated glycoprotein expressed on
thyroid cells) are the most probable mechanisms. Cross-reactivity between
antigens in the setting of genetic predisposition has been considered as a
potential mechanism that links the described association between ANCA vasculitis
and AIT.
free
free
free
