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10.1038/srep44006 http://scihub22266oqcxt.onion/10.1038/srep44006 C5339801!5339801 !28266594     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28266594 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28266594 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 44006 Nephropedia Template TP {{tp|p=28266594 |t=2017. Autaptic Connections Shift Network Excitability and Bursting |pdf=|usr=}}{{28266594 }} gab.com Text Autaptic Connections Shift Network Excitability and Bursting JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28266594 #FOAvip We examine the role of structural autapses, when a neuron synapses onto itself, in driving network-wide bursting behavior. Using a simple spiking model of neuronal activity, we study how autaptic connections affect activity patterns, and evaluate if controllability significantly affects changes in bursting from autaptic connections. Adding more autaptic connections to excitatory neurons increased the number of spiking events and the number of network-wide bursts. We observed excitatory synapses contributed more to bursting behavior than inhibitory synapses. We evaluated if neurons with high average controllability, predicted to push the network into easily achievable states, affected bursting behavior differently than neurons with high modal controllability, thought to influence the network into difficult to reach states. Results show autaptic connections to excitatory neurons with high average controllability led to higher burst frequencies than adding the same number of self-looping connections to neurons with high modal controllability. The number of autapses required to induce bursting was lowered by adding autapses to high degree excitatory neurons. These results suggest a role of autaptic connections in controlling network-wide bursts in diverse cortical and subcortical regions of mammalian brain. Moreover, they open up new avenues for the study of dynamic neurophysiological correlates of structural controllability. Twit Text FOAVip Autaptic Connections Shift Network Excitability and Bursting ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28266594 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28266594 #FOAvip English Wikipedia <ref>{{Cite pmid|28266594 }}</ref> Autaptic Connections Shift Network Excitability and Bursting #MMPMID28266594 Wiles L ; Gu S ; Pasqualetti F ; Parvesse B ; Gabrieli D ; Bassett DS ; Meaney DF Sci Rep 2017[Mar]; 7 (ä): 44006 PMID28266594 show ga We examine the role of structural autapses, when a neuron synapses onto itself, in driving network-wide bursting behavior. Using a simple spiking model of neuronal activity, we study how autaptic connections affect activity patterns, and evaluate if controllability significantly affects changes in bursting from autaptic connections. Adding more autaptic connections to excitatory neurons increased the number of spiking events and the number of network-wide bursts. We observed excitatory synapses contributed more to bursting behavior than inhibitory synapses. We evaluated if neurons with high average controllability, predicted to push the network into easily achievable states, affected bursting behavior differently than neurons with high modal controllability, thought to influence the network into difficult to reach states. Results show autaptic connections to excitatory neurons with high average controllability led to higher burst frequencies than adding the same number of self-looping connections to neurons with high modal controllability. The number of autapses required to induce bursting was lowered by adding autapses to high degree excitatory neurons. These results suggest a role of autaptic connections in controlling network-wide bursts in diverse cortical and subcortical regions of mammalian brain. Moreover, they open up new avenues for the study of dynamic neurophysiological correlates of structural controllability. |*Action Potentials [MESH] |*Synaptic Transmission [MESH] |Computer Simulation [MESH] |Models, Neurological [MESH]Autaptic Connections Shift Network Excitability and Bursting (epmc).pdf DeepDyve Pubget Overpricing