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2017 ; 8
(14
): 23937-23954
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Aurora kinases: novel therapy targets in cancers
#MMPMID28147341
Tang A
; Gao K
; Chu L
; Zhang R
; Yang J
; Zheng J
Oncotarget
2017[Apr]; 8
(14
): 23937-23954
PMID28147341
show ga
Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A
(AURKA), Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell
division via regulating mitosis especially the process of chromosomal
segregation. Besides regulating mitosis, Aurora kinases have been implicated in
regulating meiosis. The deletion of Aurora kinases could lead to failure of cell
division and impair the embryonic development. Overexpression or gene
amplification of Aurora kinases has been clarified in a number of cancers. And a
growing number of studies have demonstrated that inhibition of Aurora kinases
could potentiate the effect of chemotherapies. For the past decades, a series of
Aurora kinases inhibitors (AKIs) developed effectively repress the progression
and growth of many cancers both in vivo and in vitro, suggesting that Aurora
kinases could be a novel therapeutic target. In this review, we'll first briefly
present the structure, localization and physiological functions of Aurora kinases
in mitosis, then describe the oncogenic role of Aurora kinases in tumorigenesis,
we shall finally discuss the outcomes of AKIs combination with conventional
therapy.
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