Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26474675
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Trends+Immunol
2015 ; 36
(11
): 670-683
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Asymmetric Cell Division in T Lymphocyte Fate Diversification
#MMPMID26474675
Arsenio J
; Metz PJ
; Chang JT
Trends Immunol
2015[Nov]; 36
(11
): 670-683
PMID26474675
show ga
Immunological protection against microbial pathogens is dependent on robust
generation of functionally diverse T lymphocyte subsets. Upon microbial
infection, naïve CD4(+) or CD8(+) T lymphocytes can give rise to effector- and
memory-fated progeny that together mediate a potent immune response. Recent
advances in single-cell immunological and genomic profiling technologies have
helped elucidate early and late diversification mechanisms that enable the
generation of heterogeneity from single T lymphocytes. We discuss these findings
here and argue that one such mechanism, asymmetric cell division, creates an
early divergence in T lymphocyte fates by giving rise to daughter cells with a
propensity towards the terminally differentiated effector or self-renewing memory
lineages, with cell-intrinsic and -extrinsic cues from the microenvironment
driving the final maturation steps.