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10.1016/j.it.2015.09.004

http://scihub22266oqcxt.onion/10.1016/j.it.2015.09.004
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suck abstract from ncbi


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pmid26474675
      Trends+Immunol 2015 ; 36 (11 ): 670-683
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  • Asymmetric Cell Division in T Lymphocyte Fate Diversification #MMPMID26474675
  • Arsenio J ; Metz PJ ; Chang JT
  • Trends Immunol 2015[Nov]; 36 (11 ): 670-683 PMID26474675 show ga
  • Immunological protection against microbial pathogens is dependent on robust generation of functionally diverse T lymphocyte subsets. Upon microbial infection, naïve CD4(+) or CD8(+) T lymphocytes can give rise to effector- and memory-fated progeny that together mediate a potent immune response. Recent advances in single-cell immunological and genomic profiling technologies have helped elucidate early and late diversification mechanisms that enable the generation of heterogeneity from single T lymphocytes. We discuss these findings here and argue that one such mechanism, asymmetric cell division, creates an early divergence in T lymphocyte fates by giving rise to daughter cells with a propensity towards the terminally differentiated effector or self-renewing memory lineages, with cell-intrinsic and -extrinsic cues from the microenvironment driving the final maturation steps.
  • |*Asymmetric Cell Division/immunology [MESH]
  • |Animals [MESH]
  • |Cell Differentiation [MESH]
  • |Cell Lineage [MESH]
  • |Humans [MESH]


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