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2015 ; 10
(4
): e0122921
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Associations between renal hyperfiltration and serum alkaline phosphatase
#MMPMID25853240
Oh SW
; Han KH
; Han SY
PLoS One
2015[]; 10
(4
): e0122921
PMID25853240
show ga
Renal hyperfiltration, which is associated with renal injury, occurs in diabetic
or obese individuals. Serum alkaline phosphatase (ALP) level is also elevated in
patients with diabetes (DM) or metabolic syndrome (MS), and increased urinary
excretion of ALP has been demonstrated in patients who have hyperfiltration and
tubular damage. However, little was investigated about the association between
hyperfiltration and serum ALP level. A retrospective observational study of the
21,308 adults in the Korea National Health and Nutrition Examination Survey IV-V
databases (2008-2011) was performed. Renal hyperfiltration was defined as
exceeding the age- and sex-specific 97.5th percentile. We divided participants
into 4 groups according to their estimated glomerular filtration rate (eGFR):
>120, 90-119, 60-89, and <60 mL/min/1.73 m2. The participants with eGFR >120
mL/min/1.73 m2 showed the highest risk for MS, in the highest ALP quartiles
(3.848, 95% CI, 1.876-7.892), compared to the lowest quartile. Similarly, the
highest risk for DM, in the highest ALP quartiles, was observed in participants
with eGFR >120 ml/min/1.73 m2 (2.166, 95% CI, 1.084-4.329). ALP quartiles were
significantly associated with albuminuria in participants with eGFR ? 60
ml/min/1.73m2. The highest ALP quartile had a 1.631-fold risk elevation for
albuminuria with adjustment of age and sex. (95% CI, 1.158-2.297, P = 0.005).
After adjustment, the highest ALP quartile had a 1.624-fold risk elevation, for
renal hyperfiltration (95% CI, 1.204-2.192, P = 0.002). In addition,
hyperfiltration was significantly associated with hemoglobin, triglyceride, white
blood cell count, DM, smoking, and alcohol consumption (P<0.05). The relationship
between serum ALP and metabolic disorders is stronger in participants with an
upper-normal range of eGFR. Higher ALP levels are significantly associated with
renal hyperfiltration in Korean general population.
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