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10.1016/j.cell.2016.02.063 http://scihub22266oqcxt.onion/10.1016/j.cell.2016.02.063 C4852710!4852710 !27087445     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27087445 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27087445 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2016 ; 165 (3 ): 566-79 Nephropedia Template TP {{tp|p=27087445 |t=2016. Asprosin, a Fasting-Induced Glucogenic Protein Hormone |pdf=|usr=}}{{27087445 }} gab.com Text Asprosin, a Fasting-Induced Glucogenic Protein Hormone JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=27087445 #FOAvip Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that precisely regulate plasma glucose levels. We have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and we name it Asprosin. Asprosin is secreted by white adipose, circulates at nanomolar levels, and is recruited to the liver, where it activates the G protein-cAMP-PKA pathway, resulting in rapid glucose release into the circulation. Humans and mice with insulin resistance show pathologically elevated plasma asprosin, and its loss of function via immunologic or genetic means has a profound glucose- and insulin-lowering effect secondary to reduced hepatic glucose release. Asprosin represents a glucogenic protein hormone, and therapeutically targeting it may be beneficial in type II diabetes and metabolic syndrome. Twit Text FOAVip Asprosin, a Fasting-Induced Glucogenic Protein Hormone ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=27087445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27087445 #FOAvip English Wikipedia <ref>{{Cite pmid|27087445 }}</ref> Asprosin, a Fasting-Induced Glucogenic Protein Hormone #MMPMID27087445 Romere C ; Duerrschmid C ; Bournat J ; Constable P ; Jain M ; Xia F ; Saha PK ; Del Solar M ; Zhu B ; York B ; Sarkar P ; Rendon DA ; Gaber MW ; LeMaire SA ; Coselli JS ; Milewicz DM ; Sutton VR ; Butte NF ; Moore DD ; Chopra AR Cell 2016[Apr]; 165 (3 ): 566-79 PMID27087445 show ga Hepatic glucose release into the circulation is vital for brain function and survival during periods of fasting and is modulated by an array of hormones that precisely regulate plasma glucose levels. We have identified a fasting-induced protein hormone that modulates hepatic glucose release. It is the C-terminal cleavage product of profibrillin, and we name it Asprosin. Asprosin is secreted by white adipose, circulates at nanomolar levels, and is recruited to the liver, where it activates the G protein-cAMP-PKA pathway, resulting in rapid glucose release into the circulation. Humans and mice with insulin resistance show pathologically elevated plasma asprosin, and its loss of function via immunologic or genetic means has a profound glucose- and insulin-lowering effect secondary to reduced hepatic glucose release. Asprosin represents a glucogenic protein hormone, and therapeutically targeting it may be beneficial in type II diabetes and metabolic syndrome. |Adipose Tissue, White/metabolism [MESH] |Amino Acid Sequence [MESH] |Animals [MESH] |Antibodies/administration & dosage [MESH] |Circadian Rhythm [MESH] |Cyclic AMP-Dependent Protein Kinases/metabolism [MESH] |Cyclic AMP/metabolism [MESH] |Fasting/blood/*metabolism [MESH] |Female [MESH] |Fetal Growth Retardation/metabolism [MESH] |Fibrillin-1 [MESH] |Glucose/metabolism [MESH] |Humans [MESH] |Insulin/metabolism [MESH] |Liver/metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Obese [MESH] |Microfilament Proteins/blood/chemistry/genetics/*metabolism [MESH] |Molecular Sequence Data [MESH] |Peptide Fragments/blood/chemistry/genetics/*metabolism [MESH] |Peptide Hormones/blood/chemistry/genetics/*metabolism [MESH] |Progeria/metabolism [MESH] |Recombinant Proteins/administration & dosage [MESH]Asprosin, a Fasting-Induced Glucogenic Protein Hormone (epmc).pdf DeepDyve Pubget Overpricing