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2015 ; 13
(ä): 153
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Aspirin and multiple sclerosis
#MMPMID26123634
Tsau S
; Emerson MR
; Lynch SG
; LeVine SM
BMC Med
2015[Jun]; 13
(ä): 153
PMID26123634
show ga
Aspirin is widely used to lessen the risks of cardiovascular events. Some studies
suggest that patients with multiple sclerosis have an increased risk for some
cardiovascular events, for example, venous thromboembolism and perhaps ischemic
strokes, raising the possibility that aspirin could lessen these increased risks
in this population or subgroups (patients with limited mobility and/or
antiphospholipid antibodies). However, aspirin causes a small increased risk of
hemorrhagic stroke, which is a concern as it could potentially worsen a
compromised blood-brain barrier. Aspirin has the potential to ameliorate the
disease process in multiple sclerosis (for example, by limiting some components
of inflammation), but aspirin also has the potential to inhibit mitochondrial
complex I activity, which is already reduced in multiple sclerosis. In an
experimental setting of a cerebral ischemic lesion, aspirin promoted the
proliferation and/or differentiation of oligodendrocyte precursors, raising the
possibility that aspirin could facilitate remyelination efforts in multiple
sclerosis. Other actions by aspirin may lead to small improvements of some
symptoms (for example, lessening fatigue). Here we consider potential benefits
and risks of aspirin usage by patients with multiple sclerosis.
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