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2016 ; 6
(ä): 32599
Nephropedia Template TP
Gifford F
; Kimmitt R
; Herath C
; Webb DJ
; Melville V
; Siribaddana S
; Eddleston M
; Dhaun N
Sci Rep
2016[Sep]; 6
(ä): 32599
PMID27586642
show ga
Chronic kidney disease (CKD) is common and independently associated with
cardiovascular disease (CVD). Arterial stiffness contributes to CVD risk in CKD.
In many developing countries a considerable proportion of CKD remains
unexplained, termed CKDu. We assessed arterial stiffness in subjects with Sri
Lankan CKDu, in matched controls without CKD and in those with defined CKD.
Aortic blood pressure (BP), pulse wave velocity (PWV) and augmentation index
(AIx) were assessed in 130 subjects (50 with CKDu, 45 with CKD and 35 without
CKD) using the validated TensioMed? Arteriograph monitor. Brachial and aortic BP
was lower in controls than in CKDu and CKD subjects but no different between CKDu
and CKD. Controls had a lower PWV compared to subjects with CKDu and CKD. Despite
equivalent BP and renal dysfunction, CKDu subjects had a lower PWV than those
with CKD (8.7?±?1.5?vs. 9.9?±?2.2?m/s, p?0.01). Excluding diabetes accentuated
the differences in PWV seen between groups (controls vs. CKDu vs. CKD:
6.7?±?0.9?vs. 8.7?±?1.5?vs. 10.4?±?1.5?m/s, p?0.001 for all). Sri Lankan CKDu
is associated with less arterial stiffening than defined causes of CKD. Whether
this translates to lower cardiovascular morbidity and mortality long term is
unclear and should be the focus of future studies.