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10.1113/JP271992 http://scihub22266oqcxt.onion/10.1113/JP271992 C4945707!4945707 !27019074     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27019074 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Physiol 2016 ; 594 (14 ): 3963-80 Nephropedia Template TP {{tp|p=27019074 |t=2016. Arrhythmogenic and metabolic remodelling of failing human heart |pdf=|usr=}}{{27019074 }} gab.com Text Arrhythmogenic and metabolic remodelling of failing human heart JO: J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27019074 #FOAvip Heart failure (HF) is a major cause of morbidity and mortality worldwide. The global burden of HF continues to rise, with prevalence rates estimated at 1-2% and incidence approaching 5-10 per 1000 persons annually. The complex pathophysiology of HF impacts virtually all aspects of normal cardiac function - from structure and mechanics to metabolism and electrophysiology - leading to impaired mechanical contraction and sudden cardiac death. Pharmacotherapy and device therapy are the primary methods of treating HF, but neither is able to stop or reverse disease progression. Thus, there is an acute need to translate basic research into improved HF therapy. Animal model investigations are a critical component of HF research. However, the translation from cellular and animal models to the bedside is hampered by significant differences between species and among physiological scales. Our studies over the last 8 years show that hypotheses generated in animal models need to be validated in human in vitro models. Importantly, however, human heart investigations can establish translational platforms for safety and efficacy studies before embarking on costly and risky clinical trials. This review summarizes recent developments in human HF investigations of electrophysiology remodelling, metabolic remodelling, and ?-adrenergic remodelling and discusses promising new technologies for HF research. Twit Text FOAVip Arrhythmogenic and metabolic remodelling of failing human heart ????J Physiol http://www.kidney.de/pget.php?&tw=1&pmid=27019074 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27019074 #FOAvip English Wikipedia <ref>{{Cite pmid|27019074 }}</ref> Arrhythmogenic and metabolic remodelling of failing human heart #MMPMID27019074 Gloschat CR ; Koppel AC ; Aras KK ; Brennan JA ; Holzem KM ; Efimov IR J Physiol 2016[Jul]; 594 (14 ): 3963-80 PMID27019074 show ga Heart failure (HF) is a major cause of morbidity and mortality worldwide. The global burden of HF continues to rise, with prevalence rates estimated at 1-2% and incidence approaching 5-10 per 1000 persons annually. The complex pathophysiology of HF impacts virtually all aspects of normal cardiac function - from structure and mechanics to metabolism and electrophysiology - leading to impaired mechanical contraction and sudden cardiac death. Pharmacotherapy and device therapy are the primary methods of treating HF, but neither is able to stop or reverse disease progression. Thus, there is an acute need to translate basic research into improved HF therapy. Animal model investigations are a critical component of HF research. However, the translation from cellular and animal models to the bedside is hampered by significant differences between species and among physiological scales. Our studies over the last 8 years show that hypotheses generated in animal models need to be validated in human in vitro models. Importantly, however, human heart investigations can establish translational platforms for safety and efficacy studies before embarking on costly and risky clinical trials. This review summarizes recent developments in human HF investigations of electrophysiology remodelling, metabolic remodelling, and ?-adrenergic remodelling and discusses promising new technologies for HF research. |Animals [MESH] |Arrhythmias, Cardiac/physiopathology [MESH] |Heart Failure/*physiopathology [MESH] |Heart/physiology/*physiopathology [MESH]Arrhythmogenic and metabolic remodelling of failing human heart (epmc).pdf DeepDyve Pubget Overpricing