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10.1038/bmt.2015.127

http://scihub22266oqcxt.onion/10.1038/bmt.2015.127
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suck abstract from ncbi


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pmid26030046
      Bone+Marrow+Transplant 2015 ; 50 (9 ): 1212-6
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  • Arrhythmias in the setting of hematopoietic cell transplants #MMPMID26030046
  • Tonorezos ES ; Stillwell EE ; Calloway JJ ; Glew T ; Wessler JD ; Rebolledo BJ ; Pham A ; Steingart RM ; Lazarus H ; Gale RP ; Jakubowski AA ; Schaffer WL
  • Bone Marrow Transplant 2015[Sep]; 50 (9 ): 1212-6 PMID26030046 show ga
  • Prior studies report that 9-27% of persons receiving a hematopoietic cell transplant develop arrhythmias, but the effect on outcomes is largely unknown. We reviewed data from 1177 consecutive patients ?40 years old receiving a hematopoietic cell transplant at one center during 1999-2009. Transplant indication was predominately leukemia, lymphoma and multiple myeloma. Overall, 104 patients were found to have clinically significant arrhythmia: 43 before and 61 after transplant. Post-transplant arrhythmias were most frequently atrial fibrillation (N=30), atrial flutter (N=7) and supraventricular tachycardia (N=11). Subjects with an arrhythmia post transplant were more likely to have longer median hospital stays (32 days vs 23, P=<0.001), a greater probability of an intensive care unit admission (52% vs 7%; P<0.001), greater probability of in-hospital deaths (28% vs 3%, P<0.001), and greater probability of death within 1 year of transplant (41% vs 15%; P<0.001) compared with patients without arrhythmia at any time. In a multivariate model including age at transplant, diagnosis, history of pretransplant arrhythmia, and transplant-related variables, post-transplant arrhythmia was associated with a greater risk for death within a year of transplant (odds ratio 3.5, 95% confidence interval: 2.1, 5.9; P<0.001). Our data suggest that arrhythmias after transplants are associated with significant morbidity and mortality. A prospective study of arrhythmia in the transplant setting is warranted.
  • |*Arrhythmias, Cardiac/etiology/mortality [MESH]
  • |*Hospital Mortality [MESH]
  • |*Length of Stay [MESH]
  • |*Models, Biological [MESH]
  • |Adult [MESH]
  • |Aged [MESH]
  • |Allografts [MESH]
  • |Disease-Free Survival [MESH]
  • |Female [MESH]
  • |Follow-Up Studies [MESH]
  • |Hematologic Neoplasms/mortality/therapy [MESH]
  • |Hematopoietic Stem Cell Transplantation/*adverse effects [MESH]
  • |Humans [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]


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