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2014 ; 1
(5
): e158
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ArfGAPs: key regulators for receptor sorting
#MMPMID26046097
Shiba Y
; Randazzo PA
Receptors Clin Investig
2014[Jun]; 1
(5
): e158
PMID26046097
show ga
Mammalian cells have many membranous organelles that require proper composition
of proteins and lipids. Cargo sorting is a process required for transporting
specific proteins and lipids to appropriate organelles, and if this process is
disrupted, organelle function as well as cell function is disrupted. ArfGAP
family proteins have been found to be critical for receptor sorting. In this
review, we summarize our recent knowledge about the mechanism of cargo sorting
that require function of ArfGAPs in promoting the formation of transport
vesicles, and discuss the involvement of specific ArfGAPs for the sorting of a
variety of receptors, such as MPR, EGFR, TfR, Glut4, TRAIL-R1/DR4,
M(5)-muscarinic receptor, c-KIT, rhodopsin and ?1-integrin. Given the importance
of many of these receptors to human disease, the studies of ArfGAPs may provide
novel therapeutic strategies in addition to providing mechanistic insight of
receptor sorting.
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