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10.3389/fpubh.2015.00218

http://scihub22266oqcxt.onion/10.3389/fpubh.2015.00218
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suck abstract from ncbi


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pmid26484339
      Front+Public+Health 2015 ; 3 (ä): 218
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  • Are Geographical "Cold Spots" of Male Circumcision Driving Differential HIV Dynamics in Tanzania? #MMPMID26484339
  • Cuadros DF ; Branscum AJ ; Miller FD ; Awad SF ; Abu-Raddad LJ
  • Front Public Health 2015[]; 3 (ä): 218 PMID26484339 show ga
  • BACKGROUND: Growing evidence suggests significant geographic clustering of male circumcision (MC) in Tanzania. The impact of spatial heterogeneity of MC prevalence on HIV transmission dynamics in this country is not well documented. The aim of this study was to assess the spatial association between MC and HIV infection in Tanzania. METHODS: Data from three Demographic and Health Survey rounds conducted in Tanzania were analyzed to identify spatial associations between MC and HIV using bivariate local indicators of spatial association (LISA). Spatial clusters with low MC prevalence (MC cold spots) were identified using scan statistics. HIV incidence rates for males and females within and outside the MC cold spots were calculated. RESULTS: Local indicators of spatial association analysis indicated a significant association between MC and HIV in the northern and southwestern regions of Tanzania. Scan statistics identified two MC cold spots in the same locations. Males located outside the MC cold spots had the lowest HIV incidence rate at 0.28 per 100 person-years at risk (pyar). HIV incidence in females located outside the MC cold spots increased from 0.40/100 pyar during 2004-2008 to 0.68/100 pyar in 2008-2012. CONCLUSION: Our study provides evidence for a geographic association between MC and HIV in Tanzania. MC could be one of the key factors driving the geographical distribution of the HIV epidemic in the country. Furthermore, in areas where most males are circumcised, the HIV infection burden could be concentrating in the female population. Therefore, along with the voluntary medical MC program, efforts targeting the female population should also be considered.
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