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2016 ; 29
(3
): 695-747
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English Wikipedia
Approved Antiviral Drugs over the Past 50 Years
#MMPMID27281742
De Clercq E
; Li G
Clin Microbiol Rev
2016[Jul]; 29
(3
): 695-747
PMID27281742
show ga
Since the first antiviral drug, idoxuridine, was approved in 1963, 90 antiviral
drugs categorized into 13 functional groups have been formally approved for the
treatment of the following 9 human infectious diseases: (i) HIV infections
(protease inhibitors, integrase inhibitors, entry inhibitors, nucleoside reverse
transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and
acyclic nucleoside phosphonate analogues), (ii) hepatitis B virus (HBV)
infections (lamivudine, interferons, nucleoside analogues, and acyclic nucleoside
phosphonate analogues), (iii) hepatitis C virus (HCV) infections (ribavirin,
interferons, NS3/4A protease inhibitors, NS5A inhibitors, and NS5B polymerase
inhibitors), (iv) herpesvirus infections (5-substituted 2'-deoxyuridine
analogues, entry inhibitors, nucleoside analogues, pyrophosphate analogues, and
acyclic guanosine analogues), (v) influenza virus infections (ribavirin, matrix 2
protein inhibitors, RNA polymerase inhibitors, and neuraminidase inhibitors),
(vi) human cytomegalovirus infections (acyclic guanosine analogues, acyclic
nucleoside phosphonate analogues, pyrophosphate analogues, and oligonucleotides),
(vii) varicella-zoster virus infections (acyclic guanosine analogues, nucleoside
analogues, 5-substituted 2'-deoxyuridine analogues, and antibodies), (viii)
respiratory syncytial virus infections (ribavirin and antibodies), and (ix)
external anogenital warts caused by human papillomavirus infections (imiquimod,
sinecatechins, and podofilox). Here, we present for the first time a
comprehensive overview of antiviral drugs approved over the past 50 years,
shedding light on the development of effective antiviral treatments against
current and emerging infectious diseases worldwide.