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2014 ; 25
(10
): 2151-8
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Approaches to uremia
#MMPMID24812163
Meyer TW
; Hostetter TH
J Am Soc Nephrol
2014[Oct]; 25
(10
): 2151-8
PMID24812163
show ga
The development of dialysis was a dramatic step forward in medicine, allowing
people who would soon have died because of lack of kidney function to remain
alive for years. We have since found, however, that the "artificial kidney" does
not live up fully to its name. Dialysis keeps patients alive but not well. Part
of the residual illness that dialysis patients experience is caused by retained
waste solutes that dialysis does not remove as well as native kidney function
does. New means are available to identify these toxic solutes, about which we
currently know remarkably little, and knowledge of these solutes would help us to
improve therapy. This review summarizes our current knowledge of toxic solutes
and highlights methods being explored to identify additional toxic solutes and to
enhance the clearance of these solutes to improve patient outcomes.