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10.1152/ajplung.00376.2013 http://scihub22266oqcxt.onion/10.1152/ajplung.00376.2013 C4042190!4042190 !24727586     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24727586 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Lung+Cell+Mol+Physiol 2014 ; 306 (11 ): L957-61 Nephropedia Template TP {{tp|p=24727586 |t=2014. Applying metabolomics to uncover novel biology in ARDS |pdf=|usr=}}{{24727586 }} gab.com Text Applying metabolomics to uncover novel biology in ARDS JO: Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24727586 #FOAvip A better understanding of the pathogenesis and the resolution of the acute respiratory distress syndrome (ARDS) is needed. Although some progress has been made with the use of protein biomarkers and candidate gene studies in understanding the pathobiology of ARDS, we propose that new studies that measure the chemical breakdown products of cellular metabolism (metabolomics) may provide new insights into ARDS, in part because metabolomics targets a later point in the genomics cascade than is possible with studies of DNA, RNA, and protein biomarkers. Technological advances have made large-scale metabolomic profiling increasingly feasible. Metabolomic approaches have already achieved novel insights in nonpulmonary diseases such as diabetes mellitus and malignancy, as well as in sepsis, a major risk factor for developing ARDS. Metabolomic profiling is a promising approach to identify novel pathways in both patients at risk for developing ARDS as well as in the early phase of established ARDS. Twit Text FOAVip Applying metabolomics to uncover novel biology in ARDS ????Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24727586 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24727586 #FOAvip English Wikipedia <ref>{{Cite pmid|24727586 }}</ref> Applying metabolomics to uncover novel biology in ARDS #MMPMID24727586 Rogers AJ ; Matthay MA Am J Physiol Lung Cell Mol Physiol 2014[Jun]; 306 (11 ): L957-61 PMID24727586 show ga A better understanding of the pathogenesis and the resolution of the acute respiratory distress syndrome (ARDS) is needed. Although some progress has been made with the use of protein biomarkers and candidate gene studies in understanding the pathobiology of ARDS, we propose that new studies that measure the chemical breakdown products of cellular metabolism (metabolomics) may provide new insights into ARDS, in part because metabolomics targets a later point in the genomics cascade than is possible with studies of DNA, RNA, and protein biomarkers. Technological advances have made large-scale metabolomic profiling increasingly feasible. Metabolomic approaches have already achieved novel insights in nonpulmonary diseases such as diabetes mellitus and malignancy, as well as in sepsis, a major risk factor for developing ARDS. Metabolomic profiling is a promising approach to identify novel pathways in both patients at risk for developing ARDS as well as in the early phase of established ARDS. |Animals [MESH] |Biomarkers/metabolism [MESH] |Humans [MESH] |Metabolomics [MESH] |Proteome/metabolism [MESH] |Respiratory Distress Syndrome/*metabolism [MESH]Applying metabolomics to uncover novel biology in ARDS (epmc).pdf DeepDyve Pubget Overpricing