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2016 ; 17
(1
): 36-44
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Applications of CRISPR-Cas systems in neuroscience
#MMPMID26656253
Heidenreich M
; Zhang F
Nat Rev Neurosci
2016[Jan]; 17
(1
): 36-44
PMID26656253
show ga
Genome-editing tools, and in particular those based on CRISPR-Cas (clustered
regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated
protein) systems, are accelerating the pace of biological research and enabling
targeted genetic interrogation in almost any organism and cell type. These tools
have opened the door to the development of new model systems for studying the
complexity of the nervous system, including animal models and stem cell-derived
in vitro models. Precise and efficient gene editing using CRISPR-Cas systems has
the potential to advance both basic and translational neuroscience research.
|*Genetic Engineering
[MESH]
|*Neurosciences
[MESH]
|*Translational Research, Biomedical
[MESH]
|Animals
[MESH]
|CRISPR-Cas Systems/*physiology
[MESH]
|Clustered Regularly Interspaced Short Palindromic Repeats/*physiology
[MESH]