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2014 ; 2014
(ä): 764581
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Application of proteomics and peptidomics to COPD
#MMPMID24895607
Pelaia G
; Terracciano R
; Vatrella A
; Gallelli L
; Busceti MT
; Calabrese C
; Stellato C
; Savino R
; Maselli R
Biomed Res Int
2014[]; 2014
(ä): 764581
PMID24895607
show ga
Chronic obstructive pulmonary disease (COPD) is a complex disorder involving both
airways and lung parenchyma, usually associated with progressive and poorly
reversible airflow limitation. In order to better characterize the phenotypic
heterogeneity and the prognosis of patients with COPD, there is currently an
urgent need for discovery and validation of reliable disease biomarkers. Within
this context, proteomic and peptidomic techniques are emerging as very valuable
tools that can be applied to both systemic and pulmonary samples, including
peripheral blood, induced sputum, exhaled breath condensate, bronchoalveolar
lavage fluid, and lung tissues. Identification of COPD biomarkers by means of
proteomic and peptidomic approaches can thus also lead to discovery of new
molecular targets potentially useful to improve and personalize the therapeutic
management of this widespread respiratory disease.