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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Apoptosis
2011 ; 16
(5
): 491-501
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Apoptotic regulation of epithelial cellular extrusion
#MMPMID21399977
Andrade D
; Rosenblatt J
Apoptosis
2011[May]; 16
(5
): 491-501
PMID21399977
show ga
Cellular extrusion is a mechanism that removes dying cells from epithelial
tissues to prevent compromising their barrier function. Extrusion occurs in all
observed epithelia in vivo and can be modeled in vitro by inducing apoptosis in
cultured epithelial monolayers. We established that actin and myosin form a ring
that contracts in the surrounding cells that drives cellular extrusion. It is not
clear, however, if all apoptotic pathways lead to extrusion and how apoptosis and
extrusion are molecularly linked. Here, we find that both intrinsic and extrinsic
apoptotic pathways activate cellular extrusion. The contraction force that drives
cellular extrusion requires caspase activity. Further, necrosis does not trigger
the cellular extrusion response, but instead necrotic cells are removed from
epithelia by a passive, stochastic movement of epithelial cells.
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