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2018 ; 19
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English Wikipedia
Apoptosis: A Target for Anticancer Therapy
#MMPMID29393886
Pfeffer CM
; Singh ATK
Int J Mol Sci
2018[Feb]; 19
(2
): ä PMID29393886
show ga
Apoptosis, the cell's natural mechanism for death, is a promising target for
anticancer therapy. Both the intrinsic and extrinsic pathways use caspases to
carry out apoptosis through the cleavage of hundreds of proteins. In cancer, the
apoptotic pathway is typically inhibited through a wide variety of means
including overexpression of antiapoptotic proteins and under-expression of
proapoptotic proteins. Many of these changes cause intrinsic resistance to the
most common anticancer therapy, chemotherapy. Promising new anticancer therapies
are plant-derived compounds that exhibit anticancer activity through activating
the apoptotic pathway.
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