Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27382195
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Indian+J+Clin+Biochem
2016 ; 31
(3
): 253-9
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Apolipoprotein A-I: A Molecule of Diverse Function
#MMPMID27382195
Mangaraj M
; Nanda R
; Panda S
Indian J Clin Biochem
2016[Jul]; 31
(3
): 253-9
PMID27382195
show ga
Apolipoprotein A-I (apo A-I) an indispensable component and a major structural
protein of high-density lipoprotein (HDL), plays a vital role in reverse
cholesterol transport and cellular cholesterol homeostasis since its
identification. Its multifunctional role in immunity, inflammation, apoptosis,
viral, bacterial infection etc. has crossed its boundary of its potential of
protecting cardiovascular system and lowering cardiovascular disease risk,
attributing HDL to be known as a protective fat removal particle. Its structural
homology with prostacyclin stabilization factor has contributed to its
anti-clotting and anti-aggregatory effect on platelet which has potentiated its
cardio-protective role as well as its therapeutic efficacy against Alzheimer's
disease. The binding affinity and neutralising action against endotoxin
lipopolysaccharide, reduces the toxic manifestations of septic shock. As a
negative acute phase protein, it blocks T-cell signalling of macrophages. However
the recently identified anti-tumor activity of apo A-I has been highlighted in
various models of melanoma, lung cancer, ovarian cancer, lymphoblastic leukaemia,
gastric as well as pancreatic cancers. These cancer fighting effects are directed
towards regression of tumor size and distant metastasis by its immuno modulatory
activity as well as its clearing effect on serum lysophospholipids. This lowering
effect on lysophospholipid concentration is utilized by apo A-I mimetic peptides
to be used in retarding tumor cell proliferation and as a potential cancer
therapeutic agent. Not only that, it inhibits the tumor associated
neo-angiogenesis as well as brings down the matrix degrading enzymes associated
with tumor metastasis. However this efficient therapeutic potential of apo A-I as
an anti tumor agent awaits further future experimental studies in humans.
free
free
free
