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2014 ; 2014
(ä): 631642
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Antiviral perspectives for chikungunya virus
#MMPMID24955364
Parashar D
; Cherian S
Biomed Res Int
2014[]; 2014
(ä): 631642
PMID24955364
show ga
Chikungunya virus (CHIKV) is a mosquito-borne pathogen that has a major health
impact in humans and causes acute febrile illness in humans accompanied by joint
pains and, in many cases, persistent arthralgia lasting for weeks to years. CHIKV
reemerged in 2005-2006 in several parts of the Indian Ocean islands and India
after a gap of 32 years, causing millions of cases. The re-emergence of CHIKV has
also resulted in numerous outbreaks in several countries in the eastern
hemisphere, with a threat to further expand in the near future. However, there is
no vaccine against CHIKV infection licensed for human use, and therapy for CHIKV
infection is still mainly limited to supportive care as antiviral agents are yet
in different stages of testing or development. In this review we explore the
different perspectives for chikungunya treatment and the effectiveness of these
treatment regimens and discuss the scope for future directions.