Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24517423
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Immunol+Rev
2014 ; 258
(1
): 12-29
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Antiviral T-cell therapy
#MMPMID24517423
Leen AM
; Heslop HE
; Brenner MK
Immunol Rev
2014[Mar]; 258
(1
): 12-29
PMID24517423
show ga
Serious viral infections are a common cause of morbidity and mortality after
allogeneic stem cell transplantation. They occur in the majority of allograft
recipients and are fatal in 17-20%. These severe infections may be prolonged or
recurrent and add substantially to the cost, both human and financial, of the
procedure. Many features of allogeneic stem cell transplantation contribute to
this high rate of viral disease. The cytotoxic and immunosuppressive drugs
administered pretransplant to eliminate the host hematopoietic/immune system and
any associated malignancy, the delay in recapitulating immune ontogeny
post-transplant, the immunosuppressive drugs given to prevent graft versus host
disease (GvHD), and the effects of GvHD itself, all serve to make stem cell
transplant recipients vulnerable to disease from endogenous (latent) and
exogenous (community) viruses, and to be incapable of controlling them as quickly
and effectively as most normal individuals.
|Adoptive Transfer
[MESH]
|Animals
[MESH]
|Graft vs Host Disease/immunology/prevention & control
[MESH]