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10.1155/2015/652875 http://scihub22266oqcxt.onion/10.1155/2015/652875 C4620262!4620262 !26543874     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26543874 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26543874 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol+Res 2015 ; 2015 (ä): 652875 Nephropedia Template TP {{tp|p=26543874 |t=2015. Antitumor Responses of Invariant Natural Killer T Cells |pdf=|usr=}}{{26543874 }} gab.com Text Antitumor Responses of Invariant Natural Killer T Cells JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26543874 #FOAvip Natural killer T (NKT) cells are innate-like lymphocytes that were first described in the late 1980s. Since their initial description, numerous studies have collectively shed light on their development and effector function. These studies have highlighted the unique requirements for the activation of these lymphocytes and the functional responses that distinguish these cells from other effector lymphocyte populations such as conventional T cells and NK cells. This body of literature suggests that NKT cells play diverse nonredundant roles in a number of disease processes, including the initiation and propagation of airway hyperreactivity, protection against a variety of pathogens, development of autoimmunity, and mediation of allograft responses. In this review, however, we focus on the role of a specific lineage of NKT cells in antitumor immunity. Specifically, we describe the development of invariant NKT (iNKT) cells and the factors that are critical for their acquisition of effector function. Next, we delineate the mechanisms by which iNKT cells influence and modulate the activity of other immune cells to directly or indirectly affect tumor growth. Finally, we review the successes and failures of clinical trials employing iNKT cell-based immunotherapies and explore the future prospects for the use of such strategies. Twit Text FOAVip Antitumor Responses of Invariant Natural Killer T Cells ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26543874 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26543874 #FOAvip English Wikipedia <ref>{{Cite pmid|26543874 }}</ref> Antitumor Responses of Invariant Natural Killer T Cells #MMPMID26543874 Altman JB ; Benavides AD ; Das R ; Bassiri H J Immunol Res 2015[]; 2015 (ä): 652875 PMID26543874 show ga Natural killer T (NKT) cells are innate-like lymphocytes that were first described in the late 1980s. Since their initial description, numerous studies have collectively shed light on their development and effector function. These studies have highlighted the unique requirements for the activation of these lymphocytes and the functional responses that distinguish these cells from other effector lymphocyte populations such as conventional T cells and NK cells. This body of literature suggests that NKT cells play diverse nonredundant roles in a number of disease processes, including the initiation and propagation of airway hyperreactivity, protection against a variety of pathogens, development of autoimmunity, and mediation of allograft responses. In this review, however, we focus on the role of a specific lineage of NKT cells in antitumor immunity. Specifically, we describe the development of invariant NKT (iNKT) cells and the factors that are critical for their acquisition of effector function. Next, we delineate the mechanisms by which iNKT cells influence and modulate the activity of other immune cells to directly or indirectly affect tumor growth. Finally, we review the successes and failures of clinical trials employing iNKT cell-based immunotherapies and explore the future prospects for the use of such strategies. |Clinical Trials as Topic [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Immunotherapy/methods [MESH] |Lymphocyte Activation [MESH] |Natural Killer T-Cells/*immunology [MESH]Antitumor Responses of Invariant Natural Killer T Cells (epmc).pdf DeepDyve Pubget Overpricing