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10.1146/annurev-pharmtox-011613-135915 http://scihub22266oqcxt.onion/10.1146/annurev-pharmtox-011613-135915 C4381542!4381542 !24050701     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24050701 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Pharmacol+Toxicol 2014 ; 54 (ä): 71-94 Nephropedia Template TP {{tp|p=24050701 |t=2014. Antiparasitic chemotherapy: from genomes to mechanisms |pdf=|usr=}}{{24050701 }} gab.com Text Antiparasitic chemotherapy: from genomes to mechanisms JO: Annu Rev Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=24050701 #FOAvip Owing to the absence of antiparasitic vaccines and the constant threat of drug resistance, the development of novel antiparasitic chemotherapies remains of major importance for disease control. A better understanding of drug transport (uptake and efflux), drug metabolism and the identification of drug targets, and mechanisms of drug resistance would facilitate the development of more effective therapies. Here, we focus on malaria and African trypanosomiasis. We review existing drugs and drug development, emphasizing high-throughput genomic and genetic approaches, which hold great promise for elucidating antiparasitic mechanisms. We describe the approaches and technologies that have been influential for each parasite and develop new ideas for future research directions, including mode-of-action studies for drug target deconvolution. Twit Text FOAVip Antiparasitic chemotherapy: from genomes to mechanisms ????Annu Rev Pharmacol Toxicol http://www.kidney.de/pget.php?&tw=1&pmid=24050701 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24050701 #FOAvip English Wikipedia <ref>{{Cite pmid|24050701 }}</ref> Antiparasitic chemotherapy: from genomes to mechanisms #MMPMID24050701 Horn D ; Duraisingh MT Annu Rev Pharmacol Toxicol 2014[]; 54 (ä): 71-94 PMID24050701 show ga Owing to the absence of antiparasitic vaccines and the constant threat of drug resistance, the development of novel antiparasitic chemotherapies remains of major importance for disease control. A better understanding of drug transport (uptake and efflux), drug metabolism and the identification of drug targets, and mechanisms of drug resistance would facilitate the development of more effective therapies. Here, we focus on malaria and African trypanosomiasis. We review existing drugs and drug development, emphasizing high-throughput genomic and genetic approaches, which hold great promise for elucidating antiparasitic mechanisms. We describe the approaches and technologies that have been influential for each parasite and develop new ideas for future research directions, including mode-of-action studies for drug target deconvolution. |*Genome, Protozoan [MESH] |*Molecular Targeted Therapy [MESH] |Antiparasitic Agents/chemistry/*pharmacology [MESH] |Clinical Trials as Topic [MESH] |Drug Design [MESH] |Drug Resistance [MESH] |Genomics/methods [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Humans [MESH] |Malaria/drug therapy/genetics [MESH] |Phenotype [MESH]Antiparasitic chemotherapy: from genomes to mechanisms (epmc).pdf DeepDyve Pubget Overpricing