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2015 ; 23
(14
): 1130-43
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Antioxidants in Translational Medicine
#MMPMID26154592
Schmidt HH
; Stocker R
; Vollbracht C
; Paulsen G
; Riley D
; Daiber A
; Cuadrado A
Antioxid Redox Signal
2015[Nov]; 23
(14
): 1130-43
PMID26154592
show ga
SIGNIFICANCE: It is generally accepted that reactive oxygen species (ROS)
scavenging molecules or antioxidants exert health-promoting effects and thus
their consumption as food additives and nutraceuticals has been greatly
encouraged. Antioxidants may be beneficial in situations of subclinical
deficiency and increased demand or acutely upon high-dose infusion. However, to
date, there is little clinical evidence for the long-term benefit of most
antioxidants. Alarmingly, recent evidence points even to health risks, in
particular for supplements of lipophilic antioxidants. RECENT ADVANCES: The
biological impact of ROS depends not only on their quantities but also on their
chemical nature, (sub)cellular and tissue location, and the rates of their
formation and degradation. Moreover, ROS serve important physiological functions;
thus, inappropriate removal of ROS may cause paradoxical reductive stress and
thereby induce or promote disease. CRITICAL ISSUES: Any recommendation on
antioxidants must be based on solid clinical evidence and patient-relevant
outcomes rather than surrogate parameters. FUTURE DIRECTIONS: Such evidence-based
use may include site-directed application, time-limited high dosing, (functional)
pharmacological repair of oxidized biomolecules, and triggers of endogenous
antioxidant response systems. Ideally, these approaches need guidance by patient
stratification through predictive biomarkers and possibly imaging modalities.
|Animals
[MESH]
|Antioxidants/*pharmacology/therapeutic use
[MESH]
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